Process for the preparation of the mesylate salt trihydrate...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/52 (2006.01)

Patent

CA 2345582

The present invention is directed to a process for the preparation of the mesylate trihydrate of the (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1- yl)-1-propanol compound having the formula (I): (see formula I) The present invention is also further comprises a process for enantiomeric resolution and isolation of the (D)-(-)-tartrate salt of the compound of the formula (I).

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