C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/385, 260/468
C07D 295/16 (2006.01) C07C 275/34 (2006.01) C07D 211/46 (2006.01) C07D 211/52 (2006.01) C07D 211/70 (2006.01) C07D 215/06 (2006.01) C07D 215/08 (2006.01) C07D 215/42 (2006.01) C07D 215/44 (2006.01) C07D 217/06 (2006.01) C07D 261/02 (2006.01) C07D 265/30 (2006.01) C07D 265/36 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 295/185 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01) C07D 295/24 (2006.01) C07D 295/26 (2006.01) C07D 295/28 (2006.01) C07D 307/14 (2006.01) C0
Patent
CA 1104132
ABSTRACT OF THE DISCLOSURE The disclosure describes derivatives of 3,4,5-tri- methoxybenzene, their preparation as well as their therapeutical use, in particular as tranquillisers, myorelaxants and anti- convulsants. They are compounds of the formula I Image (I) wherein each of m and n, which may be the same or different, represents 0, 1 or 2, X represents an oxygen atom or an imine group of formula NR3 (wherein R3 represent; a hydrogen atom or a benzyl or morpholinoethyl group), Y represents cne of the divalent groups CO, CONH, COO or SO2, and NR1R2 represents a dimethylamino, diethylamino, dipropyl- amino, dibutylamino, allylamino, isobutenylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, cyclooctylamino, N-methyl N-cyclopentylamino, N-methyl N-cyclohexylamino, N-allyl N-cyclohexylamino, adamantyl- amino, diethoxyethylamino, dimethylaminoethylamino, dimethylaminopropylamino, N-methyl N-dimethylamino- propyl-amino, benzylamino, 3,4,5-trimethoxybenzylamino, phenethylamino, p-chlorophenethylamino, tetrahydrofur- furylamino, tetrahydropyranyl-methylamino, pyrrolidino, isoxazolidinyl, piperidino, 4-hydroxypiperidino, 4-p-chlorophenyl-4-hydroxypiperidino, homopiperidino, 1,2,3,6-tetrahydropyridyl, morpholino, 2-methyl- morpholino, 2,6-dimethylmorpholino, 2-morpholino- ethylamino, thiamorpholino, piperazino, 4-methylpipera- zino, 4-(?-m-chlorophenyl-benzyl)-piperazino, 4-(3,4,5- trimethoxyphenylaminocarbonyl)-piperazino, 4-(3,4,5- trimethoxyphenylaminocarbonylmethyl)-piperazino, 4- phenylpiperazino, 4-m-trifluoromethylphenyl-piperazino, 4-piperidino carbonylmethyl-piperazino, 1,2,3,4- tetrahydroquinolyl, 1,2,3,4-tetrahydroisoquinolyl, (7-chloro-4-quinolyl)-amino, 1,2,3,4-tetrahydro- benzoxazinyl or 1,2,3,4-tetrahydro-6-chloro-benzoxazinyl group, as well as their pharmaceutically acceptable acid addition salts. The compounds of the formula I may be obtained from known compounds according to the following general scheme: Image In these formulae A represents a -N=C=O, NH2, OH or -NH-(CH2)m- CO-hal group, B represents H, NH2, OH, hal-CO- or hal-SO2-, hal being a halogen, preferably chlorine atom, and NR1R2, m and n have the same meanings aq in formula I.
294802
Joullie Maurice L.
Lakah Lucien
Maillard Gabriel F.
Warolin Christian J.m.
Metabio-Joullie
Swabey Ogilvy Renault
LandOfFree
Process for the preparation of therapeutically useful... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of therapeutically useful..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of therapeutically useful... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-602130