Process for the preparation of thiazole derivatives

Details Process for the preparation of thiazole derivatives Process for the preparation of thiazole derivatives

C - Chemistry, Metallurgy

07

D

260/299, 260/242

C07D 513/04 (2006.01)

Patent

CA 1117942

ABSTRACT Thiazole derivatives of general formula (I) Image (I) in which n is 1 or 2 and Ar represents a phenyl radical unsubstituted or substituted by one or more substituents selected from halogen atoms, the radical CF3, the phenyl radical straight or branched chain alkyl radicals having 1 to 4 carbon atoms,and cycloalkyl radicals having 3 to 6 carbon atoms, and their pharmaceutically acceptable acid addition salts are useful in therapy as anti- depressive agents. They are prepared by reacting the thiazole Image with a ketone X-CH2-CO-CH2O-Ar (III) (X is a leaving group, such as halogen).

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