Process for the preparation of thrombinlike enzymes from...

C - Chemistry – Metallurgy – 12 – N

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167/103.34

C12N 9/74 (2006.01) A61K 38/48 (2006.01) C12N 9/64 (2006.01) C12Q 1/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1078732

A PROCESS FOR THE PREPARATION OF THROMBIN-LIKE ENZYMES FROM SNAKE VENOMS ABSTRACT OF THE DISCLOSURE A process for the preparation of thrombin-like proteolytic enzymes from snake venoms or fractions thereof comprising contacting the snake venom or fraction thereof with heparin insolubilized by reaction with a water-insoluble carrier in order to bind the thrombin-like enzyme to the insolubilized heparin, removing the undesirable accompany- ing substances of the snake venom and splitting the thrombin- like enzyme from the insolubilized heparin.

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