Process for the preparation of thymosin .alpha..sub.1 and an...

Details Process for the preparation of thymosin .alpha..sub.1 and an... Process for the preparation of thymosin .alpha..sub.1 and an...

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 14/575 (2006.01) C07K 5/06 (2006.01) C07K 5/068 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1113088

ABSTRACT Process for the preparation of thymosin ?1 and [Asn2]- thymosin ?1 using conventional methods, and intermediates useful in the process. Thymosin ?1 is a heat stable, highly acidic polypeptide compound of 28 amino acid residues of the following sequence: 10 H3C-CO-5er-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu Val Val-Glu-G~u-Ala-Glu-Asn-OH. This peptide is a potent and immunopotentiating agent.

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