Process for the preparation of triazolyl isopropanols

Details Process for the preparation of triazolyl isopropanols Process for the preparation of triazolyl isopropanols

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01)

Patent

CA 2051281

An improved method for the preparation of fluconazole is described, by reacting an halohydrinic intermediate with 4-amino-1,2,4-triazole compound of formula II Image wherein X is fluorine, chlorine, bromine or iodine and subsequent deamination with nitrous acid. Fluconazole is useful as a antimycotic drug.

Méthode améliorée d'obtention de fluconazole par réaction d'un intermédiaire halohydrinique avec un composé du type 4-amino-1,2,4-triazole de formule II Image où X est le fluor, le chlore le brome ou l'iode, et par désamination à l'acide nitreux. Le fluconazole est un médicament antifongique efficace.

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