C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 231/10 (2006.01) C07C 235/16 (2006.01) C07C 237/52 (2006.01)
Patent
CA 2755650
The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available .alpha.-hy-droxyacid or a salt thereof.
La présente invention concerne un procédé de préparation de composés carboxamido donnés, en particulier de dérivés de l'acide 2,4,6-triiodoisophthalique, comme intermédiaires utiles pour la préparation de produits de contraste pour imagerie aux rayons X dont l'iopamidol. Ledit procédé comprend l'étape consistant à faire réagir des composés intermédiaires N-sulfinyle appropriés avec un a-hydroxyacide disponible dans le commerce ou un sel de celui-ci.
Anelli Pier Lucio
Brocchetta Marino
Fretta Roberta
Lattuada Luciano
Mortillaro Armando
Bracco Imaging S.p.a.
Smart & Biggar
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