Process for the preparation of triterpene derivatives

Details Process for the preparation of triterpene derivatives Process for the preparation of triterpene derivatives

C - Chemistry, Metallurgy

07

J

260/4

C07J 63/00 (2006.01) A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/30 (2006.01) C07C 62/32 (2006.01) C07C 63/42 (2006.01) C07C 69/013 (2006.01) C07C 69/02 (2006.01) C07C 69/34 (2006.01) C07C 69/74 (2006.01) A61K 31/56 (2006.01)

Patent

CA 1102304

ABSTRACT OF THE DISCLOSURE The present invention provides 3.beta.-hydroxy-18.beta.-olean-9- en-30-oic acids of the formula: Image (I) and corresponding esters in the 3-position with mono- and dicarboxylic acids containing from 2 to 5 carbon atoms, as well as the pharmaceutically acceptable salts thereof with alkaline metals, amino acids and copper. These compounds have a pro- nounced anti-ulcer action and do not cause sodium retention at the effective dose levels which, together with a low toxicity of active doses, makes them very interesting pharmacologically.

298963

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