Process for the preparation of vancomycin

Details Process for the preparation of vancomycin Process for the preparation of vancomycin

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) C07K 9/00 (2006.01)

Patent

CA 2045483

Abstract The invention relates to a process for prepara- tion of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a strain belonging to the Micropolyspora species in a culture-medium containing assimilable carbon and nitrogen sources as well as mineral salts. According to the invention as microorganisms the aminoglycoside-resistant NCAIM 001092 and NCAIM 001093 mutants of the strain belonging to the Micropolyspora orientalis species are used. Nitrates are suitable mineral salts in the fermentation. Soy flour, glycerol, calcium gluconate, starch are useful carbon sources. The fermenta- tion is carried out preferably at a temperature of 29 - - 30°C. The vancomycin antibiotic produced in the fermenta- tion is separated by using reverse osmosis and ultrafiltra- tion following ion-exchange chromatography.

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