Process for the preparation of vitamin d analogues

Details Process for the preparation of vitamin d analogues Process for the preparation of vitamin d analogues

C - Chemistry, Metallurgy

07

F

C07F 7/18 (2006.01) C07C 69/732 (2006.01) C07C 69/734 (2006.01) C07D 303/32 (2006.01) C07D 303/40 (2006.01)

Patent

CA 2316157

A stereospecific method for accomplishing the below reaction: (see formula I) results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R- configuration in the compound of resulting formula 2. In the above process, R1 is C1-C6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pK a less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.

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