C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/20 (2006.01)
Patent
CA 2578559
The present invention provides a novel and improved process for the preparation of Zonisamide and the intermediates thereof. In one aspect of the present invention, the process provides for: the preparation and isolation of a novel crystalline form of anhydrous 1,2-benzisoxazole-3-methanesulfonic acid of formula 1; the direct chlorination of the acid of formula I into its acid chloride of formula 2; and the in situ conversion of the intermediate acid chloride of formula 2 into Zonisamide.
Guntoori Bhaskar Reddy
Mohamed Nageib
Rey Allan W.
Weeratunga Gamini
Wolf Eckardt C.g.
Apotex Pharmachem Inc.
Mckinnon Graham J.k.
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