Process for the production of 1-methyl-3-keto- steroids

Details Process for the production of 1-methyl-3-keto- steroids Process for the production of 1-methyl-3-keto- steroids

C - Chemistry, Metallurgy

07

J

C07J 1/00 (2006.01) C07J 9/00 (2006.01) C07J 21/00 (2006.01)

Patent

CA 2142303

Process for the production of 1-methyl-3-keto-.DELTA.1,4 steroids of general formula I (see formula I), in which St symbolizes the radical of a steroid molecule, characterized in that a 3-keto-.DELTA.1,4 steroid of general formula II (see formula II), in which St has the above-mentioned meaning, is reacted in an inert solvent in the presence of a nickel salt soluble herein with an organometallic compound of formula III, IV or V CH3 ~ Zn ~ X (III), (see formula IV), (see formula V), in which X represents a methyl group, an alkoxy group with at most 6 carbon atoms or a phenoxy radical optionally substituted by halogen atoms, alkoxy groups with at most 6 carbon atoms and/or alkyl groups with at most 6 carbon atoms, and Y1, Y2 and Y3 as well as Z1 and Z2 are the same or different and have the same meaning as X, is described.

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