Process for the production of...

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C - Chemistry, Metallurgy

07

D

260/276.1

C07D 495/04 (2006.01) C07D 211/74 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1337695

A process is disclosed for the production of 4,5,6,7-tetrahydrothieno-[3,2-c]-pyridines of the formula: Image Starting from a 4-oxo-3-piperidine-3-carboxylic acid ester of the formula: Image an allyl group is introduced in the 3-position, the ester function in the 3-position is removed, the resultant compound of the formula: Image is ozonized, reduced to the corresponding aldehyde of the formula: Image which is cyclized with H2S/HCl in the presence of a metal halide to form the desired end product. The synthesized compounds possess antithrombotic action.

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