Process for the production of...

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C - Chemistry, Metallurgy

07

D

C07D 307/60 (2006.01)

Patent

CA 2058144

A process is disclosed wherein threo-4-alkoxy-5- (arylhydroxymethyl)-2(5H)-furanones are obtained by condensation of 4-alkoxy-2(5H)-furanones with benzaldehydes in the presence of a lithium hydroxide catalyst and without contamination by the corresponding erythro stereoisomers. The condensation is preferably performed in aqueous acetonitrile and the product is precipitated from the alkaline reaction mixture by the addition of water. The products produced according to the process of the present invention are known pharmacologically active ingredients with anticonvulsive or antiepileptic action.

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