Process for the production of...

Details Process for the production of... Process for the production of...

C - Chemistry, Metallurgy

07

D

C07D 207/273 (2006.01) C07D 207/38 (2006.01)

Patent

CA 2055378

ABSTRACT OF THE DISCLOSURE A process is disclosed for the production of 4- hydroxy-2-oxopyrrolidin-1-yl-acetamide, which is a cerebrally active pharmaceutical agent. A 4-halo-3-alkoxy- butenoic acid ester is reacted with glycine to form a novel intermediate product of the formula: Image (II) wherein R represents lower alkyl. The compound II is subjected to acid hydrolysis of the alkoxy group, subsequent hydrogenation, esterification of the carboxyl function and finally conversion to the desired end product by reaction with ammonia.

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