C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/308.5
C07D 277/34 (2006.01)
Patent
CA 1188699
Improved process for the production of 2-[4-(2-thiazolyloxy)phenyl]propionic acid Abstract Improved process for the production of 2-[4-(2- thiazolyloxy)phenyl]propionic acid which comprises methylating the isopropyl, sec-butyl, tert-butyl or benzhydryl ester of 2-[4-(2-thiazolyloxy)phenyl]acetic acid with methyl bormide in dimethylformamide at -5 to 5°C in the presence of powdered potassium hydroxide and hydrolyzing the ester group with sodium hydroxide at 0 - 70°C in an aqueous alcohol solution, - 1 -
420722
Ando Satoru
Hamada Yoshinori
Johnson Douglas S. Q.c.
Shionogi & Co. Ltd.
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