Process for the production of 3'-nucleoside prodrugs

Details Process for the production of 3'-nucleoside prodrugs Process for the production of 3'-nucleoside prodrugs

C - Chemistry, Metallurgy

07

H

C07H 19/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2511616

Provided is a single-step process for the selective 3'-acylation of a ribofuranosyl 2' or 3'-branched nucleoside. These compounds are useful as antiviral agents, and in particular,can be used to treat Flaviviridae infections in a host in need t hereof.

La présente invention se rapporte à un procédé à étape unique permettant d'effectuer une 3'-acylation sélective d'un ribofuranosyl-nucleoside 2' ou 3'-ramifié. Ces composés sont utiles en tant qu'agents antiviraux, et notamment, peuvent être utilisés pour traiter les infections par <i>Flaviviridae</i> chez un sujet hôte justiciable d'un tel traitement.

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