Process for the production of 4-aminobutyric acid or its...

Details Process for the production of 4-aminobutyric acid or its... Process for the production of 4-aminobutyric acid or its...

A - Human Necessities

61

K

260/526.1, 260/5

A61K 31/19 (2006.01)

Patent

CA 1119614

ABSTRACT OF THE DISCLOSURE 4-Aminobutyric acid or its derivatives may be readily produced by a new process comprising reacting a propionic acid compound containing a carboxamido substituent (-CONH2) on the 3-carbon atom and optionally containing one or more of hydroxyl substituent protected or unprotected amino substituent and lower alkyl substituent on the 2- and/or 3-carbon atoms thereof, with an alkanoic acid anhydride or alhydride or alkanoic acid halide in a liquid tertiary amine such as pyridine to convert the carboxamido group into nitrile group, and then reducing the resultant nitrile compound with hydrogen to convert the nitrile group into aminomethyl group, and further optionally removing the residual amino-protecting group from the resultant 4- aminobutyric acid compound.

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