Process for the production of 6-hydroxynicotinic acid

Details Process for the production of 6-hydroxynicotinic acid Process for the production of 6-hydroxynicotinic acid

C - Chemistry, Metallurgy

12

P

195/131, 195/34.

C12P 17/12 (2006.01) C12N 1/20 (2006.01)

Patent

CA 1247543

PROCESS FOR THE PRODUCTION OF 6-HYDROXYNICOTINIC ACID ABSTRACT OF THE INVENTION A process is disclosed for the production of 6-hydroxynicotinic acid from nicotinic acid. The hydroxylation is carried out enzymatically in the presence of a microorganism of the genus Pseudomonas, Bacillus or Achromobacter, for example, Achromobacter xylosoxydans. Preferably the enzymatic hydroxylation is carried out at 20° to 40°C. and a pH of 5.5 to 9.0 under aerobic conditions. Also, preferably a 0.1 percent by weight solution up to a saturated (preferably a 0.5 to 10 percent by weight) nicotinic acid solution is used.

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