Process for the production of 9-(.beta.-d-...

C - Chemistry – Metallurgy – 07 – H

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260/229.5

C07H 19/20 (2006.01)

Patent

CA 1088927

ABSTRACT OF THE DISCLOSURE Process for the production of an ester product, 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate, in which 9-(.beta.-D-arabinofuranosyl)adenine is converted to a 5'-mono- phosphorylated intermediate product in the presence of a trialkyl phosphate solvent, the reaction mixture is then treated with a non-aqueous diluent in which the intermediate product is insoluble, the solid intermediate product is isolated and subjected to aqueous hydrolysis, the pH of the hydrolysis mixture being maintained so as to precipitate the ester product from the aqueous mixture, and the ester product is isolated.

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