Process for the production of 9-(.beta.-d-arabinofuranosyl)...

C - Chemistry – Metallurgy – 07 – H

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260/229.5

C07H 19/20 (2006.01)

Patent

CA 1077030

Abstract of the Disclosure: Process for the production of an ester product, 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate, in which the mixture resulting from reaction of 9-(.beta.-D-arabino- furanosyl)adenine with phosphorylating agent in tri- alkyl phosphate solvent is subjected to aqueous hydrolysis, the pH of the hydrolysis mixture is adjusted upward sufficiently to cause separation into aqueous and non-aqueous liquid phases, the trialkyl phosphate solvent is removed, and the product is precipitated from the residual aqueous mixture and isolated.

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