Process for the production of a derivative of phenylacetic acid

Details Process for the production of a derivative of phenylacetic acid Process for the production of a derivative of phenylacetic acid

C - Chemistry, Metallurgy

07

D

260/514.1

C07D 307/46 (2006.01) C07D 307/52 (2006.01) C07D 307/56 (2006.01)

Patent

CA 1095077

Case 4-337/338/339 CANADA PROCESS FOR THE PRODUCTION OF A DERIVATIVE OF PHENYLACETIC ACID Abstract of the Disclosure The present invention concerns a new process for the produc- tion of a derivative of phenylacetic acid, the o-(2,6-di- chloroanilino)-phenylacetic acid and its salts with bases which have strong antiinflammatory and antirheumatic activity. In this process a compound of the general formula I Image (I) wherein X represents the 2-furyl radical, an optionally acetalized 5-formyl-2-furyl radical or the vinyl radical, is subjected to an oxidative cleavage reaction and, if desired, the o-(2,6-dichloroanilino)-phenylacetic acid is converted into a salt with a base As an oxidant, e.g. ozone is used, if necessary followed by a further oxidant such as a per- manganic acid salt or hydrogen peroxide.

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