Process for the production of alanine by recombinant...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/74 (2006.01) A23C 19/032 (2006.01) C12N 9/06 (2006.01) C12P 13/06 (2006.01)

Patent

CA 2318526

The present invention relates to a process for preparing alanine, especially L- alanine, by culturing a genetically modified microorganism that is able to produce alanine from glucose, characterized in that the microorganism used is one whose native sugar metabolism has been diverted to alanine formation, especially L-alanine formation, in such a manner that essentially more than 40 %, preferably more than 60 % and more preferably more than 75 % of the carbon consumed from the medium is converted into alanine, especially via pyruvate. The microorganism is preferably a homofermentative microorganism, especially a lactic acid bacterium, more particularly (a strain of) L. lactis, and is preferably a food-grade microorganism. The invention can be used for both the in situ and the stereospecific preparation of alanine. The invention also relates to the microorganisms and recombinant DNA molecules that can be used in the invention and to the alanine and alanine-containing (food) products obtained according to the invention.

L'invention concerne un procédé servant à préparer de l'alanine, en particulier L-alanine, ce qui consiste à effectuer la culture d'un micro-organisme génétiquement modifié capable de produire l'alanine à partir du glucose. Ce procédé est caractérisé par le fait que le micro-organisme utilisé est un micro-organisme dont le métabolisme d'origine du sucre a été détourné vers la production d'alanine, en particulier la production de L-alanine, de sorte que plus de 40 %, de préférence plus de 60 % et, dans un mode de réalisation préféré, plus de 75 % du carbone consommé par le milieu de culture est converti en alanine, particulièrement par l'intermédiaire de pyruvate. Ce micro-organisme est, de préférence, un micro-organisme homofermentaire, en particulier, une bactérie d'acide lactique, plus particulièrement (une souche de) L.lactis et, de préférence, un micro-organisme de catégorie alimentaire. On peut mettre cette invention en application afin de préparer l'alanine à la fois in situ et de façon stéréospécifique. Elle concerne également les micro-organismes et les molécules d'ADN de recombinaison pouvant être utilisés, ainsi qu'alanine et les produits (alimentaires) contenant alanine que l'invention permet d'obtenir.

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