Process for the production of antiulceratives

Details Process for the production of antiulceratives Process for the production of antiulceratives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) C07B 45/04 (2006.01)

Patent

CA 2389163

The invention relates to a method for producing therapeutic agents for ulcers, according to the general formula (I). In said formula, R1, R2 and R3 represent hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 fluoroalkyl and C1-C8 alkoxy, R3 and R4 represent hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, CH2-C3-C8 cycloalkyl, C1-C8 alkoxycarbonyl, C1-C8 alkoxy, C1-C8 fluoroalkoxy, CF3, C2-C8 fluoroalkyl and C(O)O-C1-C8- alkyl and R6 represents hydrogen and C1-C2 alkyl. According to said method, a compound in accordance with formula (II) is reacted with m-chloroperoxybenzoic acid in a solvent, the pH value of this reaction mixture is subsequently increased above pH 7.0, the solvent is optionally removed and the crystals of the compound according to formula (I) are then separated. The method is characterized in that the solvent is acetone, or a mixture of acetone and water.

L'invention concerne un procédé de fabrication amélioré de dérivés de benzimidazole, en particulier d'oméprazole ou de pantoprazole, servant d'agents thérapeutiques dans le traitement des ulcères.

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