Process for the production of aqueous mixed micelle solutions

Details Process for the production of aqueous mixed micelle solutions Process for the production of aqueous mixed micelle solutions

A - Human Necessities

61

K

167/195

A61K 31/575 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2029673

A process for the production of aqueous mixed micelle solutions, containing mixed micelles formed from lipids and salts of bile acids, in which optionally slightly water-soluble or water-insoluble active ingredients are solubilized, is described, which is characterized in that mixtures are prepared from a) solutions which contain lipids, free bile acids and optionally slightly water-soluble or water-insoluble active ingredients in a water-soluble organic solvent and b) solutions which contain 0.05 to 3 equivalents of bases and optionally isotonized additives and/or water-soluble active ingredients in relation to the bile acids, the organic solvent is removed by ultrafiltration, freeze-drying, vacuum distillation or reverse osmosis, and the mixture obtained is optionally diluted with aqueous phase.

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