Process for the production of bivalirudin

Details Process for the production of bivalirudin Process for the production of bivalirudin

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) C07K 14/815 (2006.01)

Patent

CA 2744627

The present invention relates to a process for the production of bivalirudin, a 20-mer peptide of formula H-D-Phe1--Pro-Arg-Pro-Gly5-Gly-Gly-Gly-Asn-Gly10-Asp-Phe-Glu-Glu-lle15- -Pro- Glu-Glu-Tyr-Leu20-OH (I) via a convergent five-fragment synthesis, and to several peptide intermediates thereof.

La présente invention concerne un procédé pour la production de bivalirudine, un peptide 20-mère de formule H-D-Phe1-Pro-Arg-Pro-Gly5-Gly-Gly-Gly-Asn-Gly10-Asp-Phe-Glu-Glu-lle15-Pro-Glu-Glu-Tyr-Leu20-OH (I) via une synthèse convergente à cinq fragments, et plusieurs intermédiaires peptidiques de celle-ci.

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