Process for the production of capsular polyosides and...

Details Process for the production of capsular polyosides and... Process for the production of capsular polyosides and...

A - Human Necessities

61

K

167/135, 195/139

A61K 39/02 (2006.01) A61K 39/102 (2006.01) C12P 19/04 (2006.01)

Patent

CA 1206905

- 23 - PROCESS FOR THE PRODUCTION OF CAPSULAR POLYOSIDES, CAPSULAR POLYOSIDES OBTAINED THEREBY, AND THEIR APPLICATION TO THE PREPARATION OF VACCINES. ABSTRACT OF THE DISCLOSURE The present invention relates to a process for the production of capsular polyosides from capsulated bacteriae containing same, comprising cultivating the bacteriae in a synthetic or semi-synthetic medium; at the end of the growth stage of said culture separating the microbial bodies from a supernatant phase; submitting said supernatant phase to a filtration through a membrane which retains the molecules of a molecular weight of 100,000 daltons or more, to give a capsular polyoside-rich retained material; and removing the proteins, the nucleic acids and the lipids from said retained material, to give a purified capsular polyoside.

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