Process for the production of carboxamides of...

C - Chemistry – Metallurgy – 07 – D

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260/243.21

C07D 279/02 (2006.01) C07D 265/02 (2006.01)

Patent

CA 1038387

ABSTRACT OF THE DISCLOSURE Disclosed heroin is an improved process for the production of carboxamides of 3,4-dihydro-oxo-1,2-benzothiazine-1,1-dioxides, Said process comprises contacting either a 3-oxo- or 4-oxo-1,2- benzothiazine-1,1-dioxide with a known or readily prepared iso- cyanate to produce the corresponding 4- or 3-carboxamide followed by a transamidation with an amine whose own isocyanate is frequently unstable to produce carboxamide with previously disclosed pharma- ceutical value as a non-steroidal antiinflammatory agent.

234551

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