Process for the production of cs particles and microcapsules...

Details Process for the production of cs particles and microcapsules... Process for the production of cs particles and microcapsules...

A - Human Necessities

61

K

A61K 9/50 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2559477

The invention relates to a method for producing CS particles (10) and microcapsules (12). According to said method, (A) at least one active ingredient (4) is adsorbed into porous templates (2), forming templates (5) filled with active ingredients; (B) the templates (2) are then provided with a base layer (6) which simplifies the subsequent formation of the capsule envelope (9); (C) said capsule envelope is obtained by applying alternately charged polyelectrolyte layers (8), forming filled CS particles (10); (D) the active ingredients (4) are released into the microcapsule by subsequent dissolution of the templates (2); and (E) the active ingredients (4) remain enclosed in the microcapsule or are slowly released therefrom.

L'invention concerne un procédé pour produire des particules de type coeur-écorce (10) et des microcapsules (12). Ce procédé comprend les étapes suivantes: (A) au moins un principe actif (4) est adsorbé dans des matrices poreuses (2), ce qui permet d'obtenir des matrices (5) remplies de principes actifs; (B) les matrices (2) sont ensuite pourvues d'une couche de base (6), dans le but de faciliter la formation ultérieure de l'enveloppe (9) de la capsule; (C) l'enveloppe de la capsule est formée par application de couches de polyélectrolytes (8) chargés en alternance de manière positive et négative, ce qui permet d'obtenir des particules de type coeur-écorce chargées; (D) la matrice (2) est ensuite dissoute, ce qui provoque la libération des principes actifs (4) présents dans la matrice et leur passage à l'intérieur de la microcapsule; (E) les principes actifs (4) restent enfermés dans cette dernière ou sont libérés lentement de la capsule.

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