C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/697 (2006.01) C07B 57/00 (2006.01) C07C 45/67 (2006.01) C07C 45/78 (2006.01) C07C 45/79 (2006.01)
Patent
CA 2342201
A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chromatography. The chromatography comprises a liquid mobile phase comprising at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from the amylosic, cellulosic, chitosan, xylan, curdlan, dextran, and inulan class of polysaccharides.
L'invention concerne un procédé relatif à la production de sertraline-tétralone énantiomériquement pure ou enrichie optiquement, à partir d'un mélange renfermant deux énantiomères, via une chromatographie continue. Ladite chromatographie comprend une phase liquide mobile à au moins un solvant polaire et une phase chirale stationnaire solide à polysaccharide dérivatisé choisi entre les catégories suivantes de polysaccharides : amylosique, cellulosique, chitosane, xylane, curdlane, dextrane et inulane.
Dapremont Oliver
Geiser Fiona
Guhan Subramanian S.
Guinn Robert M.
Quallich George J.
Pfizer Products Inc.
Smart & Biggar
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