Process for the production of heparin

Details Process for the production of heparin Process for the production of heparin

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) C12S 3/02 (2006.01)

Patent

CA 2294780

The invention relates to a simplified process for the extraction of heparin from animal mucosa tissue. The method consists of an enzymatic hydrolysis step of the raw material at ambient temperature, followed by hydrolysis for up to 6 hours at a temperature of 50-75 °C. Raise in temperature is obtained by easy means. The digestion mixture can be further incubated while cooling down to ambient temperature. Heparin is recovered from anion exchanger present in the protein hydrolysate.

L'invention concerne un procédé simplifié permettant d'extraire l'héparine du tissu de la muqueuse chez les animaux. Le procédé consiste à effectuer l'hydrolyse enzymatique de matière première à température ambiante, puis à effectuer l'hydrolyse qui dure jusqu'à 6 heures à un température comprise entre 50 et 75 DEG C. Il est aisé d'augmenter la température. Le mélange de digestion peut être ensuite incubé tout en étant refroidi à une température ambiante. L'héparine est récupérée à partir d'un échangeur d'anions présent dans l'hydrolysat des protéines.

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