Process for the production of high affinity anti-hapten...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C07K 16/44 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2074590

ABSTRACT The invention relates to a process for the production of high-affinity anti-hapten antibodies and to a composition for the determination of haptens with the aid of these antibodies. The process for the production of these high- affinity anti-hapten antibodies is characterised in that in a first step an animal is immunised several times with a hapten-protein conjugate and in the second step the animal is immunised several times with a mixture of up to three hapten-protein conjugates, the conjugates con- taining the same hapten, but different proteins.

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