Process for the production of indoles

Details Process for the production of indoles Process for the production of indoles

C - Chemistry, Metallurgy

07

D

260/319.7

C07D 209/04 (2006.01)

Patent

CA 1127163

ABSTRACT OF THE DISCLOSURE: Indoles of the formula: Image (wherein R is hydrogen, halogen, 1-5C alkyl, 1-5C alkoxy, 1-5C alkylthio, 1-5C alkylsulfonyl, or 2-10C dialkylamino; and n is an integer from 1 to 3) are prepared by reductively cyclizing a compound of the formula: Image (wherein X is halogen, and R and n have the same signifi- cances as given earlier) in an inert solvent medium. The indoles are useful as synthetic intermediates for the production of dyestuffs, perfumes, or medicinals, especially alkaloids. The new process is industrial and economical.

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