Process for the production of indoles

Details Process for the production of indoles Process for the production of indoles

C - Chemistry, Metallurgy

07

D

260/319.6

C07D 209/16 (2006.01) C07D 209/18 (2006.01)

Patent

CA 1230602

A B S T R A C T Title: PROCESS FOR THE PRODUCTION OF Indoles A process is disclosed for the preparation of an indole of general formula (I) (I) Image wherein R1 represents H or C1-6 alkyl or C3-6 alkenyl, R2 represents H or C1-3 alkyl, C3-6 alkenyl, aryl, ar(C1-4)alkyl or C5-7 cycloalkyl, R3 represents H or C1-3 alkyl group; R4 and R5, represent H or a C1-3 alkyl or propenyl group or together form an aralkylidene group; and Alk represents a C2-3 alkylene chain, or a physiologically acceptable salt or solvate thereof which comprises reacting an indole of general formula (II): Image (II) (wherein X represents a leaving group) witll an amine R1R2NH. The indoles of formula (I) are indicated for use in the treatment of migraine.

469527

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