Process for the production of l-carnitine by way of...

Details Process for the production of l-carnitine by way of... Process for the production of l-carnitine by way of...

C - Chemistry, Metallurgy

12

P

195/134.2, 195/3

C12P 13/00 (2006.01) C12N 1/20 (2006.01)

Patent

CA 1265757

PROCESS FOR THE PRODUCTION OF L-CARNITINE BY WAY OF MICROBIOLOGY ABSTRACT OF THE INVENTION A process is disclosed for the production of L-carnitine utilizing a microorganism. The microorganism is cultivated with crotonobetaine and/or ? -butyrobetaine in the presence of a growth substrate and the enriched L-carnitine is isolated. The microorganisms used are those which are capable of producing L-carnitine from crotonobetaine and/or ? -butyrobetaine while not catabolizing it. The microorganisms can be obtained by the following selection method. Microorganisms which grow with betaine, ? -butyrobetaine, crotonobetaine and L-carnitine as the C- and N-source are mutated in conventional manner. From the culture obtained by cultivating the mutated microorganisms, those microorganisms are selected which are stable, do not catabolize L-carnitine and do not grow on L-carnitine, crotonobetaine and ? -butyrobetaine, but grow with betaine.

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