Process for the production of microcapsules

Details Process for the production of microcapsules Process for the production of microcapsules

B - Operations, Transporting

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B01J 13/02 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) B01J 13/04 (2006.01) B01J 13/12 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2126685

2126685 9409898 PCTABS00032 Described is a method of manufacturing microcapsules from biodegradable polymers, the method using biodegradable solvents and producing microcapsules which are free from toxic solvent residues. The solvents used include simple esters made from a C1-C5 alcohol and a C1-C5 monocarboxylic acid, as well as mixtures of such esters, and the solvent can also contain a C1-C5 alcohol. Both water-soluble and water-insoluble active substances can be incorporated in the microcapsules. Water-soluble active substances such as drugs, peptides, proteins, enzymes and vaccins are preferably dispersed as an aqueous solution in the polymer solution. The microcapsules are produced by spraying a solution, suspension or water-in-oil dispersion of active substances and biodegradable polymers. The method is suitable for use in the manufacture of drug, vaccin and enzyme preparations.

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