C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.06
C07K 5/06 (2006.01) C07K 1/02 (2006.01) C07K 5/075 (2006.01)
Patent
CA 1302648
ABSTRACT OF THE DISCLOSURE There is disclosed a process for producing N-formyl-?-L-aspartyl-phenylalanine methyl ester. The process comprises reacting N-formyl-L-aspartic acid anhydride and L-phenylalanine methyl ester in a reaction solvent and in the presence of acetic acid or a mixture of acetic acid and formic acid in a complete mixing type continuous reaction mode. This process has the advantage that it is possible to greatly increase the ratio between N-formyl-?-L-aspartyl-L- phenylalanine methyl ester and its isomer, the N-formyl-.beta.-L- -aspartyl-L-phenylalanine methyl ester, in the reaction product.
524335
Kawasaki Haruo
Nakamura Masao
Tsuji Toshiaki
Yamashita Takashi
Yukawa Toshihide
Ajinomoto Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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