Process for the production of pancreatin pellets

A - Human Necessities – 61 – K

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167/165, 167/103

A61K 9/20 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 35/39 (2006.01) A61K 38/46 (2006.01)

Patent

CA 1142082

ABSTRACT OF THE DISCLOSURE Pancreatin pellets are produces by a process employing extrusion techniques. In the process, a mixture of pancreatin powder and selected solvent is formed into a pliable mass suitable for extrusion. The extrusion is conducted followed by a cutting, shaping or forming of the extruded mass into pre- pellet like forms. Further drying and mechanical working of the pre-pellet forms results in the final pancreatin pellet of improved pharmaceutical and mechanical stability. A special aspect of the process is the selection of a solvent for mixing with pancreatin powder that is harmless to enzymes. Such solvents typically include isopropanol and acetone.

353493

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