Process for the production of particles

B - Operations – Transporting – 01 – D

Patent

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Details

B01D 9/00 (2006.01) A61K 9/16 (2006.01) B01F 11/02 (2006.01) C30B 7/00 (2006.01) C30B 7/02 (2006.01)

Patent

CA 2516733

A process for the production of particles comprises the steps of formation of a solution of a desired substance in a suitable solvent; ii)generation of an aerosol from the solution of said substance; iii) collection of the aerosol droplets in a vessel containing a non-solvent of said substance; and iv) application of ultrasound to the droplets dispersed in the non-solvent to effect crystallisation of said substance. The particles produced find application in for example pharmaceutical and agrochemical formulations, especially in inhalation formulations.

L'invention concerne un procédé de production de particules consistant i) à former une solution d'une substance souhaitée dans un solvant approprié, ii) à générer un aérosol à partir de la solution de ladite substance, iii) à rassembler les gouttelettes d'aérosol dans un récipient contenant un non-solvant de cette substance et iv) à appliquer des ultrasons sur les gouttelettes dispersées dans le non-solvant afin de provoquer la cristallisation de ladite substance. Les particules produites s'appliquent par exemple à des formulations pharmaceutiques et agrochimiques, notamment à des formulations pour inhalation.

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