Process for the production of substituted sulphoximides

Details Process for the production of substituted sulphoximides Process for the production of substituted sulphoximides

C - Chemistry, Metallurgy

07

D

260/291.3, 260/3

C07D 295/12 (2006.01) C07C 161/00 (1980.01)

Patent

CA 1102803

ABSTRACT OF THE DISCLOSURE Novel substituted sulphoximides of the general formula Image in which R1 and R2 independently of each other represent phenyl, R3 and R4 which may be the same or different represent optionally substituted straight chain or branched lower alkyl, or together with the nitrogen atom, form a pyrrolidino, piperidino or morpholino ring, R5 represents a hydrogen atom or a straight chain or branched lower alkyl group, X is an inorganic or organic anion of a physiologically compatible acid and n has the value 0 or 1 are prepared by reacting an S,S-diaryl sulphoximide of the general formula Image II with formaldehyde and a secondary amine of the formula Image if desired with conversion to a tertiary salt by reaction with a compound R5X. The compounds show pharmacological activity in particular as spasmolytics.

345046

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