Process for the production of tertiary alcohols

Details Process for the production of tertiary alcohols Process for the production of tertiary alcohols

C - Chemistry, Metallurgy

07

B

C07B 49/00 (2006.01) C07C 29/147 (2006.01) C07C 31/12 (2006.01) C07C 31/135 (2006.01) C07D 215/18 (2006.01)

Patent

CA 2692919

Tertiary alcohols are prepared by reacting carboxylic esters with Grignard reagents in ethereal solvents in the presence of lanthanum trichloride and lithium chloride. The method is particularly suitable for the production of (.alpha.S)-.alpha.-[3-[(1E)-2-(7- chloro-2-quino- linyl)ethenyl]phenyl]-2-(1-hydroxy-1- methylethyl)benzenepropanol of formula (A) which is an intermediate in the production of montelukast.

L'invention concerne des alcools tertiaires qui sont préparés par réaction d'esters carboxyliques avec des réactifs de Grignard dans des solvants de type éthers en présence de trichlorure de lanthane et de chlorure de lithium. Le procédé est particulièrement approprié pour la production de (aS)-á-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethényl]phényl]-2-(1-hydroxy-1-méthyléthyl)benzènepropanol de formule (A) qui est un intermédiaire dans la production du montélukast.

Affiliated with

Also associated with

Rating

Process for the production of tertiary alcohols does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of tertiary alcohols, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of tertiary alcohols will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1412285