Process for the production of the dexfenfluramine hydrochloride

Details Process for the production of the dexfenfluramine hydrochloride Process for the production of the dexfenfluramine hydrochloride

C - Chemistry, Metallurgy

07

C

C07C 211/29 (2006.01) C07C 209/08 (2006.01) C07C 209/62 (2006.01) C07C 211/26 (2006.01)

Patent

CA 2215001

Process for the production of the anorexic drug dexfenfluramine hydrochloride (INN) which comprises the ethylation of the (S),(S)-N-1- phenylethyl)-.alpha.-methyl-3(trifluoromethyl)benzeneethanamine or of a salt thereof with an organic or inorganic acid, the debenzylation of the resulting intermediate (S),(S)-N-ethyl-N-(1-phenylethyl).alpha.-methyl-3- (trifluoromethyl)benzeneethanamine or of a salt thereof with an organic or inorganic salt by catalytic hydrogenation and, optionally, the salification with hydrochloric acid.

Un procédé de production du médicament anorexigène hydrochlorure de dexfenfluramine (INN) qui comprend l'éthylation de la (S),(S)-N-1-phényléthyl)-.alpha.-méthyl-3(trifluorométhyl)benzèneéthanamine ou d'un sel correspondant avec un acide organique ou minéral, la débenzylation de la (S),(S)-N-éthyl-N-(1-phényléthyl).alpha.-méthyl-3-(trifluorométhyl)benzèneéthanamine (produit intermédiaire) ou d'un sel correspondant avec un acide organique ou minéral par hydrogénation catalytique et, facultativement, la salification avec de l'acide chlorhydrique.

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