Process for the production of thrombin and high purity...

Details Process for the production of thrombin and high purity... Process for the production of thrombin and high purity...

C - Chemistry, Metallurgy

12

N

195/78, 195/33.1

C12N 9/74 (2006.01) A61K 38/49 (2006.01)

Patent

CA 2034826

ABSTRACT IMPROVED PROCESS FOR THE PRODUCTION OF THROMBIN AND HIGH PURITY THROMIBIN PREPARATIONS THEREBY OBTAINED A process for the production of a liquid thrombin preparation comprises reacting each unit of prothrombin wiwth less than 50% of the conventional thromboplastin input in the presence of calcium, contacting the resultant thrombin with a phosphate buffer, and diluting and filtering the suspension. The filtrate is then applied sequentially to an anion-exchange agarose column and a cation-exchange agarose column and the thrombin fraction is step-wise eluted from the latter column with phosphate buffered saline. Liquid thrombin preparations thereby obtained have specific activities greater than 1,600 U/mg and can be used in haemostasis.

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