C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2450384
The present invention provides a process for the production of N-[3(3- cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N- ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.
La présente invention concerne un procédé de production de N-[3(3-cyanopyrazolo[1,5-a]pyrimidine-7-yle)phényle]-N-éthylacétamide (Zaleplon), en l'occurrence, un principe actif approuvé pour le traitement de l'insomnie. En l'occurrence, on prend du N-[3-[3-(diméthylamino)-1-oxo-2-propényle]phényle]-N-éthylacétamide, ou l'un de ses sels, et on le fait réagir avec du 3-amino-4-cyanopyrazole, ou l'un de ses sels, dans des conditions acides dans un milieu de réaction comprenant un mélange d'eau et d'un composé organique miscible avec l'eau.
Feher Erika
Korodi Ferenc
Magyar Erika
Biogal Gyogyszergyar Rt.
Heenan Blaikie Llp
Teva Gyogyszergyar Reszvenytarsasag
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