Process for the purification of a 3-cephem-4-carboxylic acid...

Details Process for the purification of a 3-cephem-4-carboxylic acid... Process for the purification of a 3-cephem-4-carboxylic acid...

C - Chemistry, Metallurgy

07

D

C07D 501/18 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2124322

The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4- carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem- 4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(Z/E)-1-propen-1-yl]- 3-cephem-4-carboxylic acid or by adsorption chromatography.

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