Process for the purification of benzphetamine hydrochloride

C - Chemistry – Metallurgy – 07 – C

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C07C 209/84 (2006.01) C07C 211/27 (2006.01)

Patent

CA 2588993

The present invention relates to the economical and separation of benzphetamine hydrochloride and methamphetamine by liquid extraction. An extraction process employing a suitable organic solvent and water at a pH in the range of from about 6 to about 8 provides excellent removal of the methamphetamine by dissolution in the water phase while the benzphetamine dissolves in the organic phase. Simple separation of the two phases results in separation of the two amines.

L'invention porte sur la séparation économique d'hydrochlorure de benzphétamine et de méthamphétamine par extraction liquide. Elle concerne aussi un procédé d'extraction utilisant un solvant organique convenable et de l'eau présentant un pH compris entre 6 et 8 environ, permettant d'extraire parfaitement de la méthamphétamine par dissolution dans la phase aqueuse alors que la benzphétamine se dissout dans la phase organique. La séparation simple des deux phases entraîne la séparation des deux amines.

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