Process for the purification of gabapentin

Details Process for the purification of gabapentin Process for the purification of gabapentin

C - Chemistry, Metallurgy

07

C

C07C 227/40 (2006.01) C07C 229/28 (2006.01)

Patent

CA 2547197

A process for the preparation of gabapentin comprising the passage of a salt of the same through a ionic exchange resin of strong cationic type, the elution of the gabapentin which has fixed onto the column and the crystallization from organic solvent, characterized in that the resin is regenerated by using a mineral acid in a molar quantity between 50 and 90%, is described.

L'invention concerne un processus de préparation de gabapentine comprenant le passage d'un sel similaire à travers une résine d'échange ionique de type cationique fort, l'élution de la gabapentine fixée sur la colonne et la cristallisation à partir d'un solvant organique. Ledit processus est caractérisé en ce que la résine est régénérée au moyen d'un acide minéral dans une quantité molaire comprise entre 50 et 90 %.

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