Process for the purification of peptides

Details Process for the purification of peptides Process for the purification of peptides

C - Chemistry, Metallurgy

07

K

530/7.36

C07K 14/585 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1046053

PROCESS FOR THE PURIFICATION OF PEPTIDES Abstract of the Disclosure Peptides of the calcitonin type when obtained by synthesis can be purified in a simple manner by forming inner salts, which precipitate from aqueous solutions of salts of the peptides with acids or bases when these solutions are adjusted to the isoelectric range. Impurities remain in solution, while the inner salts separate prac- tically quantitatively. The precipitation is completed after several hours. The peptides can then be recuperated by treatment with an acid, especially a therapeutically suitable acid. The process affords products which are superior to those obtained by purification methods hitherto known and gives higher yields. Other long- chain peptides such as ACTH, insulin or glucagon cannot be purified in this manner.

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