Process for the purification of tacrolimus

Details Process for the purification of tacrolimus Process for the purification of tacrolimus

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) C07B 63/00 (2006.01)

Patent

CA 2586193

A process for the purification and recovery of Tacrolimus (I) (17-allyl-1,14- dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methyvinyl]-23,25-dimethoxy- 13,19,21,27-tetramethyl-11,28-dioxi-4-azatricyclo-[22.3.1.04,9]octacos-18-en- 2,3,10,16-tetraone), starting from Streptomyces sp fermentation broth. The process is particularly advantageous in terms of productivity and selectivity of the separation of impurities.

La présente invention concerne un procédé de purification et de récupération de Tacrolimus (I) (17-allyl-1,14- dihydroxy-12-[2-(4-hydroxy-3-méthoxycyclohexyl)-1-méthyvinyl]-23,25-diméthoxy-13,19,21,27-tétraméthyl-11,28-dioxi-4-azatricyclo-[22.3.1.04,9]octacos-18-en-2,3,10,16-tétraone), à partir d'un bouillon de fermentation de Streptomyces sp. Ce procédé est particulièrement intéressant en termes de productivité et de sélectivité de la séparation des impuretés. Formule (I)

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