Process for the removal of the formyl group from n- formyl...

Details Process for the removal of the formyl group from n- formyl... Process for the removal of the formyl group from n- formyl...

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/06 (2006.01) C07K 1/12 (2006.01) C07K 5/075 (2006.01)

Patent

CA 1244406

TITLE OF THE INVENTION PROCESS FOR THE REMOVAL OF THE FORMYL GROUP FROM N-FORMYL PEPTIDES AND ESTERS THEREOF ABSTRACT OF THE DISCLOSURE A process for the removal of the formyl group in N-formyla ted peptides or their esters is described. The N-formyl compound is reacted with hydrazine or a substituted hydra- zine of formula I: Image at a pH between 1 and 3.5, keeping the pH constant during the reaction. The process is particularly useful for the preparation of aspartam. - 2 -

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